Selianskaia N A, Ryzhko I V, Verkina L M, Trishina A V, Mironova A V, Akulova M V
Antibiot Khimioter. 2011;56(1-2):18-21.
Analysis of the antibioticograms of the Vibrio cholerae non-01/non-0139 strains showed that in the cultures isolated in the Rostov Region in 1968--1975 there were present markers of resistance to ampicillin (7%), kanamycin (15.8%), rifampicin (3.5%) and trimetoprim/sulfamethoxazole (14%). Among the strains isolated in the Ukraine in 1975 14% was resistant to ampicillin. More than a half of the strains isolated in Uzbekistan in 1990 and 2000-2001, in the Arkhangelsk Region in 1999-2000 and in the Kalmykia in 1999-2005 was antibiotic resistant. In the above regions the strains were resistant to ampicillin (12.5-44.4%), kanamycin (11-55%), rifampicin (1.9-12.5%) and trimetoprim/sulfamethoxazole (25-62.5%). Among the cultures isolated in Uzbekistan in 1990 and 2000-2001 25 and 7.8% were resistant to furazolidone and 31.25% was resistant to streptomycin (1990). All the cultures isolated in the Rostov Region in 2005-2009 were resistant to ampicillin, 50% was resistant to ceftazidim, 57% was resistant to streptomycin and furazolidone, 7.2% was resistant to kanamycin and 14% was resistant to trimetoprim/sulfamethoxazole. The studies revealed an increase of the extent of the V.cholerae non-01/non-0139 resistance spectrum within 1968-2009, simultaneous presence of up to 5 diverse resistance markers and a variety of their combinations, that requires the use of antibacterials for the treatment of the diseases due to the vibrios in strict compliance with the pathogen antibioticogram and their early replace by more efficient drugs.
对霍乱弧菌非O1/非O139菌株的抗菌谱分析表明，在1968 - 1975年罗斯托夫地区分离出的培养物中，存在对氨苄西林（7%）、卡那霉素（15.8%）、利福平（3.5%）和甲氧苄啶/磺胺甲恶唑（14%）的耐药标记。在1975年乌克兰分离出的菌株中，14%对氨苄西林耐药。1990年以及2000 - 2001年在乌兹别克斯坦、1999 - 2000年在阿尔汉格尔斯克地区和1999 - 2005年在卡尔梅克分离出的菌株中，超过一半具有抗生素耐药性。在上述地区，菌株对氨苄西林（12.5 - 44.4%）、卡那霉素（11 - 55%）、利福平（1.9 - 12.5%）和甲氧苄啶/磺胺甲恶唑（25 - 62.5%）耐药。在1990年以及2000 - 2001年乌兹别克斯坦分离出的培养物中，25%和7.8%对呋喃唑酮耐药，31.25%对链霉素耐药（1990年）。2005 - 2009年在罗斯托夫地区分离出的所有培养物均对氨苄西林耐药，50%对头孢他啶耐药，57%对链霉素和呋喃唑酮耐药，7.2%对卡那霉素耐药，14%对甲氧苄啶/磺胺甲恶唑耐药。研究揭示了1968 - 2009年间霍乱弧菌非O1/非O139耐药谱范围的增加、同时存在多达5种不同的耐药标记及其多种组合，这就要求在治疗由弧菌引起的疾病时，严格根据病原体抗菌谱使用抗菌药物，并尽早用更有效的药物替代。
