Selianskaia N A, Ryzhko I V, Verkina L M, Trishina A V, Mironova A V
Antibiot Khimioter. 2011;56(7-8):16-21.
Inducible character of resistance to tetracycline, chloramphenicol and ampicillin was investigated in 20 strains of Vibrio cholera non-O1/non-O139 serogroups isolated from inhabitants of Uzbekistan in 1990 (10 strains, ctx+) and in 2001 (5 strains, ctx-) and from inhabitants of Kalmykiya within 2003-2005 (5 strains, ctx-). Eight of the 20 isolates showed not only capacity for induction of the antibiotic resistance, but also its possible self transfer to Escherichia coli and reverse crosses in El Tor V. cholerae P-5879. It was shown that the effect of the antibacterial on the isolates phenotypic susceptibility could increase the resistance markers expression, when the genomes contained sites responsible for their expression, that required constant bacteriological control of the treatment efficacy and the use of the isolates antibioticograms for early replace of the inefficient drug by the efficient one. The prevalence of V. cholerae O1 and non-O1/non-O13 serogroups with multiple resistance to the antibacterial and the genetic potency for the antibiotic resistance development in the pathogen made difficult the choice of efficient drugs for prophylaxis and treatment of diseases caused by V. cholerae.
对1990年从乌兹别克斯坦居民中分离出的20株霍乱弧菌非O1/非O139血清群（10株，ctx+）、2001年从乌兹别克斯坦居民中分离出的（5株，ctx-）以及2003 - 2005年从卡尔梅克居民中分离出的（5株，ctx-）菌株，研究了对四环素、氯霉素和氨苄青霉素耐药性的可诱导特性。20株分离株中有8株不仅表现出诱导抗生素耐药性的能力，还表现出其可能自我转移至大肠杆菌以及在埃尔托型霍乱弧菌P - 5879中进行反向杂交的能力。结果表明，当基因组中含有负责表达的位点时，抗菌药物对分离株表型敏感性的影响可增加耐药标记的表达，这就需要对治疗效果进行持续的细菌学监测，并利用分离株的抗生素谱尽早用高效药物替换低效药物。霍乱弧菌O1和非O1/非O13血清群对抗菌药物多重耐药的流行情况以及病原体中抗生素耐药性发展的遗传潜力，使得选择用于预防和治疗霍乱弧菌所致疾病的高效药物变得困难。
