α-氨基膦酸酯/次膦酸酯结构基序在药物化学中的显著潜力。 - Suppr

Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry.

作者信息

Mucha Artur, Kafarski Paweł, Berlicki Łukasz

机构信息

Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wrocław, Poland.

出版信息

J Med Chem. 2011 Sep 8;54(17):5955-80. doi: 10.1021/jm200587f. Epub 2011 Aug 5.

DOI:10.1021/jm200587f

PMID:21780776

Abstract

摘要

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Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry.α-氨基膦酸酯/次膦酸酯结构基序在药物化学中的显著潜力。

J Med Chem. 2011 Sep 8;54(17):5955-80. doi: 10.1021/jm200587f. Epub 2011 Aug 5.

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Enantiodifferentiation of N-benzyloxycarbonylaminophosphonic and phosphinic acids and their esters using cyclodextrins by means of capillary electrophoresis.利用环糊精通过毛细管电泳法对N-苄氧羰基氨基膦酸和次膦酸及其酯进行对映体拆分

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Recent synthesis of aminophosphonic acids as potential biological importance.近期合成的氨基膦酸作为具有潜在生物学重要性的化合物。

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Asymmetric preference of serine proteases toward phosphonate and phosphinate esters.丝氨酸蛋白酶对膦酸酯和次膦酸酯的不对称偏好。

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Remarkable potential of the α-aminophosphonate/phosphinate structural motif in medicinal chemistry.

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