产时使用克林霉素对阴道B族链球菌菌落计数的影响。
The effect of intrapartum clindamycin on vaginal group B streptococcus colony counts.
作者信息
Knight Kristin M, Thornburg Loralei L, McNanley Anna R, Hardy Dwight J, Vicino David, Glantz J Christopher
机构信息
Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of Rochester Strong Memorial Hospital, USA.
出版信息
J Matern Fetal Neonatal Med. 2012 Jun;25(6):747-9. doi: 10.3109/14767058.2011.591458. Epub 2011 Jul 22.
OBJECTIVE
To determine the temporal relationship between intrapartum clindamycin and vaginal Group B Streptococcus (GBS) colony counts.
METHODS
In this prospective observational study, women with GBS-positive, clindamycin-sensitive, antenatal rectovaginal cultures, intrapartum vaginal cultures were collected just before the first clindamycin dose (T(0)) and then every 2 h for 8 h or until delivery. Colony counts were quantified using serial dilution. Results were standardized as percent of initial colony count and analyzed using sequential Friedman tests.
RESULTS
Twenty-one women had positive intrapartum vaginal GBS cultures at T(0). With T(0) colony counts standardized to 100%, subsequent percents-of-baseline fell rapidly and significantly by T(2) and fell further at each subsequent point, reaching 0% by T(6). For 12 women cultured for the full 8 hours, the decline in GBS was significant at p < 0.001.
CONCLUSIONS
Vaginal GBS colony counts fall rapidly after intrapartum clindamycin administration, similar to declines after penicillin. This represents a possible mechanism for efficacy of chemoprophylaxis.
目的
确定产时使用克林霉素与阴道B族链球菌（GBS）菌落计数之间的时间关系。
方法
在这项前瞻性观察性研究中，对GBS阳性、对克林霉素敏感的孕妇进行产前直肠阴道培养，在首次给予克林霉素剂量前（T(0)）采集产时阴道培养物，然后每2小时采集一次，共采集8小时或直至分娩。使用系列稀释法对菌落计数进行定量。结果以初始菌落计数的百分比进行标准化，并使用序贯Friedman检验进行分析。
结果
21名女性在T(0)时产时阴道GBS培养呈阳性。将T(0)时的菌落计数标准化为100%后，随后的基线百分比在T(2)时迅速且显著下降，并在随后的每个时间点进一步下降，到T(6)时降至0%。对于12名培养了整整8小时的女性，GBS的下降在p < 0.001时具有显著性。
结论
产时给予克林霉素后，阴道GBS菌落计数迅速下降，与青霉素治疗后的下降情况相似。这代表了化学预防有效性的一种可能机制。
Zotero 插件