Division of Sport Science, Konkuk University, Chungju, Republic of Korea.
Int J Food Sci Nutr. 2012 Feb;63(1):103-6. doi: 10.3109/09637486.2011.602051. Epub 2011 Jul 25.
Chitosan, which is derived from chitin, has drawn much attention due to its low toxicity and potential use in medical and pharmaceutical applications. The biological activities of chitosan have been shown to depend on its molecular weight (MW) and degree of deacetylation. In this study, we investigated whether oral chitooligosaccharides, which are easily absorbed into the body, can reduce the plasma level of lipid in smokers and non-smokers because smoking is a high-risk factor for cardiovascular diseases. All healthy men (11 smokers and 8 non-smokers) consumed 500 mg of chitooligosaccharides in water twice daily before a meal (breakfast and dinner) over a 6-week period. Total cholesterol and low-density lipoprotein cholesterol levels were significantly decreased in both the smoker group and non-smoker group when compared with baseline. These results suggest that low MW chitooligosaccharides would be an effective dietary supplement for lowering cholesterol level.
壳聚糖来源于几丁质，由于其低毒性和在医学和制药应用中的潜在用途，引起了广泛关注。壳聚糖的生物学活性取决于其分子量（MW）和脱乙酰度。在这项研究中，我们研究了是否可以通过口服易被人体吸收的壳寡糖来降低吸烟者和非吸烟者的血浆脂质水平，因为吸烟是心血管疾病的高危因素。所有健康男性（11 名吸烟者和 8 名不吸烟者）在 6 周的时间内，每天饭前（早餐和晚餐）两次在水中服用 500 毫克壳寡糖。与基线相比，吸烟者和非吸烟者的总胆固醇和低密度脂蛋白胆固醇水平均显著降低。这些结果表明，低 MW 壳寡糖将是降低胆固醇水平的有效膳食补充剂。
