Bahijri Suhad M, Alsheikh Lubna, Ajabnoor Ghada, Borai Anwar
Department of Clinical Biochemistry, Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Saudi Diabetes Research Group, King Abdulaziz University (KAU), Jeddah, Saudi Arabia.
Nutr Metab Insights. 2017 May 22;10:1178638817710666. doi: 10.1177/1178638817710666. eCollection 2017.
The aim was to investigate effect of chitosan on markers of obesity and cardiometabolic risk in rats fed normal chow (NC) or high-fat/high-cholesterol diet (HF/HCD). Forty male rats were fed NC or HF/HCD for 3 months, then divided into 4 groups: group A fed NC, group B: NC + chitosan, group C: HF/HCD, and group D: HF/HCD + chitosan. Food intake and weight were recorded, and serum glucose, lipid profile, insulin, leptin, gamma glutamyl transferase (GGT), and tumor necrosis factor α were measured at beginning and after 12 weeks. Atherogenic index (AI), low-density lipoprotein cholesterol:high-density lipoprotein cholesterol (LDL-C:HDL-C), and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. At the end of study, food intake was significantly increased in group B; mean values of triglycerides, total cholesterol, LDL-C, LDL-C:HDL-C, and AI were decreased in group B and group D; mean leptin was increased in group A and decreased in group B; and mean values of insulin, HOMA-IR, and GGT were increased in group C. The results from this study suggest that chitosan improved lipid profile, insulin sensitivity, and oxidative stress caused by HF/HCD.
目的是研究壳聚糖对喂食普通饲料（NC）或高脂/高胆固醇饮食（HF/HCD）的大鼠肥胖及心脏代谢风险标志物的影响。40只雄性大鼠喂食NC或HF/HCD 3个月，然后分为4组：A组喂食NC，B组：NC+壳聚糖，C组：HF/HCD，D组：HF/HCD+壳聚糖。记录食物摄入量和体重，并在实验开始时及12周后测量血清葡萄糖、血脂谱、胰岛素、瘦素、γ-谷氨酰转移酶（GGT）和肿瘤坏死因子α。计算致动脉粥样硬化指数（AI）、低密度脂蛋白胆固醇：高密度脂蛋白胆固醇（LDL-C:HDL-C）和胰岛素抵抗稳态模型评估（HOMA-IR）。在研究结束时，B组食物摄入量显著增加；B组和D组甘油三酯、总胆固醇、LDL-C、LDL-C:HDL-C和AI的平均值降低；A组瘦素平均值升高，B组降低；C组胰岛素、HOMA-IR和GGT的平均值升高。本研究结果表明，壳聚糖改善了HF/HCD引起的血脂谱、胰岛素敏感性和氧化应激。
