Doré J C, Viel C, Pageot N, Gordaliza M, Castro A, del Corral J M, Feliciano A S
Laboratoire de Chimie appliquée aux corps organisés, CNRS URA 4O1, Muséum National d'Histoire Naturelle, Paris, France.
J Pharm Belg. 1996 Jan-Feb;51(1):9-18.
In this work, the authors have used technics of multivariate analysis to determine the structure-activity relationships of 46 podophyllotoxin derivatives and analogs studied for their antineoplastic and antiviral activities. The obtained results allow to envisage the possible synthesis of more specific molecules by making modifications in the structure of the model molecular archetype.
在这项工作中，作者运用多变量分析技术来确定46种鬼臼毒素衍生物及类似物的构效关系，这些衍生物及类似物已针对其抗肿瘤和抗病毒活性进行了研究。所获结果使人们能够设想，通过对模型分子原型的结构进行修饰，有可能合成出更具特异性的分子。
