中波紫外线 A1 光疗对局限性硬皮病的疗效。
Effectiveness of medium-dose ultraviolet A1 phototherapy in localized scleroderma.
机构信息
Department of Dermatology, Bezmialem Vakif University, Faculty of Medicine Neoson Imaging Center, Radiology Department of Pathology, Vakif Gureba Teaching and Research Hospital, Istanbul, Turkey.
出版信息
Int J Dermatol. 2011 Aug;50(8):1006-13. doi: 10.1111/j.1365-4632.2010.04843.x.
BACKGROUND
Recently, ultraviolet (UV) A1 phototherapy has been suggested as an effective treatment for localized scleroderma (LS); however, the optimal dose of UVA1 still has not been determined.
OBJECTIVE
We aimed to evaluate the therapeutic effectiveness of medium-dose (30 J/cm(2) ) UVA1 phototherapy and to show that 13MHz ultrasound is a valuable tool for assessing the results of UVA1 phototherapy in LS.
METHODS
Thirty-five patients with LS were treated with medium-dose (30J/cm(2) ) UVA1. In total, 30-45 treatments and 900-1350J/cm(2) cumulative UVA1 doses were evaluated by clinical scoring in all patients. In 14 patients, skin thickness was also determined by 13MHz ultrasound examination.
RESULTS
In all patients, medium-dose UVA1 therapy softened sclerotic plaques, and marked clinical improvement was observed in 29 of 35 (82. 85%) patients. Ultrasound measurements showed that skin thickness was significantly reduced. No side effects were observed during or after treatment.
CONCLUSION
Medium-dose UVA1 phototherapy is a highly effective, safe, and well-tolerated therapeutic modality for treatment of all types of LS. A 13MHz ultrasound probe may be used for evaluating UVA1 phototherapy results.
背景
最近，紫外线 A1 光疗已被提议作为治疗局限性硬皮病（LS）的有效方法；然而，UVA1 的最佳剂量仍未确定。
目的
我们旨在评估中剂量（30J/cm2）UVA1 光疗的疗效，并表明 13MHz 超声是评估 LS 中 UVA1 光疗结果的一种有价值的工具。
方法
35 例 LS 患者接受中剂量（30J/cm2）UVA1 治疗。在所有患者中，通过临床评分评估了 30-45 次治疗和 900-1350J/cm2 累积 UVA1 剂量。在 14 例患者中，还通过 13MHz 超声检查测量皮肤厚度。
结果
在所有患者中，中剂量 UVA1 治疗使硬化斑块软化，35 例患者中的 29 例（82.85%）观察到明显的临床改善。超声测量显示皮肤厚度显著减少。治疗过程中和治疗后均未观察到不良反应。
结论
中剂量 UVA1 光疗是治疗所有类型 LS 的一种高效、安全且耐受良好的治疗方法。13MHz 超声探头可用于评估 UVA1 光疗效果。
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