低剂量紫外线A光疗治疗局限性硬皮病
Low-dose UVA phototherapy for treatment of localized scleroderma.
作者信息
Kerscher M, Volkenandt M, Gruss C, Reuther T, von Kobyletzki G, Freitag M, Dirschka T, Altmeyer P
机构信息
Department of Dermatology, Ruhr-University Bochum, Germany.
出版信息
J Am Acad Dermatol. 1998 Jan;38(1):21-6. doi: 10.1016/s0190-9622(98)70533-x.
BACKGROUND
For treatment of localized scleroderma numerous treatments, including ones with potentially hazardous side effects, are currently used with only limited success.
OBJECTIVE
We attempted to determine the efficacy of low-dose UVA1 irradiation in patients with severe localized scleroderma.
METHODS
Patients were irradiated with 20 J/cm2 UVA1 for 12 weeks (total number of treatments: 30; cumulative UVA1 dose: 600 J/cm2).
RESULTS
Low-dose UVA1 irradiation induced significant clinical improvement (clearance of > 80% of lesions) in 18 of 20 patients. Clearance was documented by clinical score as well as by 20 MHz ultrasound and histopathologic analysis.
CONCLUSION
Low-dose UVA1 phototherapy can be highly effective for sclerotic plaques, even in patients with advanced localized scleroderma and with lesions rapidly evolving despite conventional therapy.
背景
对于局限性硬皮病的治疗，目前使用了多种治疗方法，包括一些具有潜在有害副作用的方法，但效果有限。
目的
我们试图确定低剂量UVA1照射对重度局限性硬皮病患者的疗效。
方法
患者接受20 J/cm²的UVA1照射，持续12周（治疗总次数：30次；UVA1累积剂量：600 J/cm²）。
结果
20例患者中有18例经低剂量UVA1照射后临床症状显著改善（病变清除率>80%）。临床评分、20 MHz超声及组织病理学分析均证实了病变的清除。
结论
低剂量UVA1光疗对硬化斑块可能非常有效，即使是晚期局限性硬皮病患者，且尽管接受了传统治疗，病变仍在快速进展。
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