Department of Diabetes and Endocrinology, Northern General Hospital, Sheffield, UK.
Diabet Med. 2012 Feb;29(2):232-5. doi: 10.1111/j.1464-5491.2011.03385.x.
A 26-year-old man with Type 1 diabetes presented with an overdose of 4800 units of the long-acting insulin analogue, glargine (Lantus). Glucose supplementation of approximately 800 g/day was associated with acute hepatic injury.
On day 4, a depot of insulin was excised from the patient's abdominal wall; this was followed by a reduction in his glucose requirements and improvement in liver function.
This report highlights the risk of acute hepatic injury during the treatment of insulin overdose and the importance of careful glucose supplementation. It also demonstrates how earlier excision of an insulin depot could potentially prevent this problem and hasten recovery.
一名 26 岁的 1 型糖尿病患者过量服用了 4800 单位的长效胰岛素类似物甘精胰岛素（Lantus）。每天补充约 800 克葡萄糖会导致急性肝损伤。
在第 4 天，从患者腹壁切除了一处胰岛素储存库；随后，他的血糖需求减少，肝功能改善。
本报告强调了在胰岛素过量治疗期间发生急性肝损伤的风险，以及谨慎补充葡萄糖的重要性。它还表明，早期切除胰岛素储存库可能有助于预防这种问题并加速恢复。
