Department of Medicine University of California San Diego.
J Thromb Haemost. 2011 Jul;9 Suppl 1(0 1):20-25. doi: 10.1111/j.1538-7836.2011.04355.x.
Integrins are cell surface adhesion and signaling receptors important for cell adhesion, survival and migration. Integrins are known to be regulated by signals from inside the cells. Such inside-out regulation modulates affinities of integrins for their extracellular matrix ligand and is critical for thrombosis, haemostasis and immune response. Talin and kindlin, two integrin binding proteins, have been shown to be important regulators of integrin function. In this review, we will focus on the molecular mechanism of integrin regulation that has emerged from recent structural, biochemical and genetic studies.
整合素是细胞表面的黏附和信号受体，对于细胞黏附、存活和迁移非常重要。整合素受细胞内信号的调节。这种内向外的调节方式调节了整合素与细胞外基质配体的亲和力，对于血栓形成、止血和免疫反应至关重要。整合素结合蛋白 talin 和 kindlin 已被证明是整合素功能的重要调节因子。在这篇综述中，我们将重点介绍最近的结构、生化和遗传研究中出现的整合素调节的分子机制。
