A 组链球菌对宿主止血系统的探索：寻找新型抗菌治疗方法的启示。
Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapies.
机构信息
Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA.
出版信息
J Thromb Haemost. 2011 Jul;9 Suppl 1(Suppl 1):189-94. doi: 10.1111/j.1538-7836.2011.04316.x.
Abstract
The haemostatic system is heavily involved in the host response to infection. A number of host haemostatic factors, notably plasminogen and fibrinogen have been reported to bind and interact with various bacterial proteins. This review summarises the roles of host haemostatic factors such as plasminogen, factor V and fibrinogen in host defence against group A streptococcus infection and discusses the potential of targeting the host haemostatic system for therapeutic intervention against infectious diseases.
摘要
止血系统在宿主对感染的反应中起着重要作用。已有报道称，许多宿主止血因子，特别是纤溶酶原和纤维蛋白原，与各种细菌蛋白结合并相互作用。本文总结了纤溶酶原、因子 V 和纤维蛋白原等宿主止血因子在宿主防御 A 组链球菌感染中的作用，并讨论了针对宿主止血系统进行治疗干预以对抗传染病的潜力。
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Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel antimicrobial therapies.A 组链球菌对宿主止血系统的探索：寻找新型抗菌治疗方法的启示。
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