Institute of Pathology, Charite, Chariteplatz 1, D-10118 Berlin, Germany.
Diagn Pathol. 2011 Jul 22;6:2-9. doi: 10.1186/1746-1596-6-68.
To analyze the hypothesis of events or neighborhood interactions that is based upon recognizable structures of systems which possess a surface in a four dimensional space-time constellation {x, y, z, t}. To include the theory of hierarchic order of structures and aspects of thermodynamically open systems, especially entropy, structural entropy and entropy flow.
Any structure is a space-time constellation that occupies a unique space in its environment. The environment can be a system too, and is assumed to be (nearly) constant. Structures can interact in their environment and create a new structure at a higher order level. Interacting structures that create a surface are called a system. Starting from the bottom, such a system is characterized by its inner structures, its surface function, and its neighborhood. Interaction with a neighboring system is called an event. An event can alter a system, create new systems or induce the decay of a system, dependent upon the surrounding lower level system (background).
The hypothesis results in a uniform theory about matter, life, diseases, or behavior. Concrete applications permit the estimation of duration of life in man, for example the effect of solid cancer in man, or appearance of protozoans in sexual or asexual reduplication. In addition, it can successfully describe the development of the universe (small exceed of matter above antimatter at the big bang), or the increase of structures (and systems) with increasing time (development of intelligent systems). The three dimensional space possesses the lowest number of mandatory dimensions to implement such a system.
分析基于具有四维时空中的表面的系统的可识别结构的事件或邻域相互作用的假设。包括结构层次秩序的理论和热力学开放系统的方面，特别是熵、结构熵和熵流。
任何结构都是一个时空排列，在其环境中占据独特的空间。环境也可以是一个系统，并且假设是（几乎）恒定的。结构可以在其环境中相互作用，并在更高阶层次上创建新结构。相互作用的创建表面的结构称为系统。从底部开始，这样的系统的特征是其内部结构、表面功能和邻域。与相邻系统的相互作用称为事件。事件可以改变系统、创建新系统或诱导系统衰减，这取决于周围的低级系统（背景）。
该假设导致了一个关于物质、生命、疾病或行为的统一理论。具体应用允许估计人类的寿命，例如人类实体瘤的影响，或原生动物在有性或无性复制中的出现。此外，它可以成功地描述宇宙的发展（大爆炸时物质超过反物质的微小过剩），或随着时间的增加结构（和系统）的增加（智能系统的发展）。三维空间具有实施这样的系统的最低必需维度数。
