Department of D.M.C.C.C., Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy.
Int J Immunopathol Pharmacol. 2011 Apr-Jun;24(2 Suppl):83-7. doi: 10.1177/03946320110240S215.
Squamous cell carcinoma is the most frequent malignant tumour of the oral cavity. It is widely known that tobacco and alcohol consumption are the major causes of the development of oral squamous cell carcinoma (OSCC). The human papilloma virus infection has also been postulated as a risk factor for squamous cell carcinoma, although conflicting results have been reported. The aim of this study is to evaluate the presence of high-risk and low-risk type human papillomavirus in a large sample of squamous cell carcinoma limited to the oral cavity by means of quantitative real-time polymerase chain reaction. Data were obtained from 278 squamous cell carcinoma limited to oral cavity proper. Sequencing revealed that 5 samples were positive for HPV type 16, 5 for HPV type 11, and 1 for HPV type 6. Human papillomavirus 11 was detected in 5 tumours out of the 278 examined. The prevalence rate for Human papillomavirus 11 was 1.8% (C.I. 0.7-3.9). The matched case-controls analysis indicated that the prevalence among controls did not significantly differ with respect to cases and that Human papillomavirus 11 alone did not correlate with squamous cell carcinoma.
鳞状细胞癌是口腔最常见的恶性肿瘤。众所周知，烟草和酒精的使用是口腔鳞状细胞癌（OSCC）发展的主要原因。人乳头瘤病毒（HPV）感染也被认为是鳞状细胞癌的一个危险因素，尽管有相互矛盾的结果报道。本研究的目的是通过定量实时聚合酶链反应（PCR）评估大量局限于口腔的鳞状细胞癌中高危和低危型人乳头瘤病毒的存在。数据来自 278 例局限于口腔的鳞状细胞癌。测序显示，5 例 HPV 16 型阳性，5 例 HPV 11 型阳性，1 例 HPV 6 型阳性。在 278 例检查的肿瘤中，有 5 例检测到 HPV 11 型。HPV 11 的流行率为 1.8%（CI：0.7-3.9）。配对病例对照分析表明，对照组与病例组之间的流行率无显著差异，HPV 11 单独与鳞状细胞癌无关。
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