Li Lin, An Li-feng, Meng Cui-da, Zhu Xue-wei, Dong Zhen, Zhu Dong-dong
Department of Otorhinolaryngology Head and Neck Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2011 May;46(5):397-401.
To investigate the basic clinical features of non-allergic rhinitis (NAR) in age, sex, incentives, and the effect of treatment with combined intranasal steroids and antihistamines.
One hundred consecutive NAR patients were included in this study and the age, gender, predisposing factors and clinical symptoms were analyzed. Combined intranasal steroids and antihistamines used for 8 weeks, the symptoms were recorded before and after treatment with visual analogue scale(VAS) score as the assessment of treatment effects. SPSS 17.0 software was used to analyze the data.
Ninety-three NAR patients were adults, and the sex ratio was 1:1.2 (male:female), and the peak age incidence was between 30 - 39 years old. The main nasal symptoms were sneezing (96 cases), rhinorrhea (88 cases), nasal blockage (72 cases) and nasal itching (69 cases). The symptoms of eye and respiratory tract were always accompanied as eye itching (49 cases), tears (32 cases), congestion (22 cases), swelling (13 cases), cough (21 cases), suffocation (19 cases), chest compression (13 cases), wheezing (10 cases); Seventy-nine (79.0%) patients could indicate at least one kind of incentives, the temperature change (54 cases), dust (28 cases), irritating odor (21 cases) was the main incentive of NAR. Forty-seven patients completed the combined treatment of intranasal steroids and antihistamines, 38 (80.9%) patients were satisfied with the result with all symptoms relieved except wheezing (P < 0.05), but 36 patients had the NAR returned when they were exposed with the predisposing factors in the coming year; the remaining 9 (19.1%) patients failed the treatment.
The clinical features of NAR were as follows: adult constituted the main patient population, women were slightly more than man but with no difference between genders; sneezing and nasal discharge were the main clinical symptoms, always more than 1 incentives. The combination of intranasal steroids and antihistamines could control the most of clinical symptoms.
探讨非变应性鼻炎（NAR）在年龄、性别、诱发因素方面的基本临床特征，以及鼻用糖皮质激素和抗组胺药联合治疗的效果。
本研究纳入100例连续的NAR患者，分析其年龄、性别、诱发因素及临床症状。采用鼻用糖皮质激素和抗组胺药联合治疗8周，治疗前后用视觉模拟评分法（VAS）记录症状，以评估治疗效果。使用SPSS 17.0软件进行数据分析。
93例NAR患者为成年人，男女比例为1:1.2（男:女），发病高峰年龄在30 - 39岁。主要鼻部症状为打喷嚏（96例）、流涕（88例）、鼻塞（72例）和鼻痒（69例）。眼部和呼吸道症状常伴随出现，如眼痒（49例）、流泪（32例）、充血（22例）、肿胀（13例）、咳嗽（21例）、憋气（19例）、胸部压迫感（13例）、喘息（10例）；79例（79.0%）患者可指出至少一种诱发因素，温度变化（54例）、灰尘（28例）、刺激性气味（21例）是NAR的主要诱发因素。47例患者完成了鼻用糖皮质激素和抗组胺药的联合治疗，38例（80.9%）患者对治疗结果满意，所有症状均缓解，但喘息除外（P < 0.05），然而36例患者在次年接触诱发因素时NAR复发；其余9例（19.1%）患者治疗失败。
NAR的临床特征如下：以成年人为主，女性略多于男性，但性别差异无统计学意义；打喷嚏和流涕是主要临床症状，诱发因素常不止一种。鼻用糖皮质激素和抗组胺药联合治疗可控制大部分临床症状。
