Department of Dermatology and Venereology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey.
Dermatitis. 2011 Jul-Aug;22(4):E10-2.
Black rubber is mainly an occupational source of contact sensitization; however, several unusual causes of non-occupational black rubber allergy are reported in the literature. A 10-year-old nonatopic Turkish boy with palmar hyperhidrosis developed acute vesicular bilateral palmar dermatitis following 2 to 3 weeks of intensive use of a new bicycle. The handgrips of the bicycle were made of black rubber. Patch testing showed a strong positive reaction to N-isopropyl-N-phenyl-4-phenylenediamine (the main sensitizer in black rubber) and questionable papular reactions to pieces of the black rubber handgrip. Additional cross-sensitization was found to p-phenylenediamine. There was no previous contact with black rubber or with any material that would contain p-phenylenediamine (eg, black henna dye). In conclusion, this was an unusual pediatric case of non-occupational allergic contact dermatitis from N-isopropyl-N-phenyl-4-phenylenediamine in black rubber bicycle handgrips. The young age of the patient and the development of contact sensitization within a relatively short period were striking. The release of the sensitizer from black rubber and the skin penetration were possibly enhanced by continuous friction and the accompanying hyperhidrosis, suggesting that the black rubber bicycle handgrip was the primary source of sensitization.
黑色橡胶主要是职业性接触致敏物；然而，文献中也有一些非职业性黑色橡胶过敏的罕见原因报道。一名 10 岁非特应性土耳其男孩，手掌多汗，在使用新自行车 2 至 3 周后，手掌突发急性水疱性双侧皮炎。自行车的手柄是黑色橡胶制成的。斑贴试验对 N-异丙基-N-苯基-4-苯二胺（黑色橡胶的主要致敏原）呈强阳性反应，对黑色橡胶手柄的片状物呈可疑丘疹反应。还发现对间苯二胺有交叉致敏反应。患儿之前无黑色橡胶接触史，也未接触过任何可能含有间苯二胺的物质（如黑色指甲花染料）。总之，这是一个非职业性接触性皮炎的不常见儿科病例，由黑色橡胶自行车手柄中的 N-异丙基-N-苯基-4-苯二胺引起。患儿年龄较小，在相对较短的时间内发生接触致敏，这一点很明显。致敏原从黑色橡胶中的释放和皮肤穿透可能因持续摩擦和伴随的多汗而增强，这表明黑色橡胶自行车手柄是致敏的主要来源。
