抗氧化剂对顺铂诱导犬呕吐的止吐活性。
Antiemetic activity of antioxidants against cisplatin-induced emesis in dogs.
机构信息
Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi 110029, India.
出版信息
Environ Toxicol Pharmacol. 1996 May 15;1(3):179-84. doi: 10.1016/1382-6689(96)00008-7.
Antioxidants such as glutathione, N-(2-mercaptopropionyl)glycine (MPG), vitamin E, vitamin C and a combination of vitamin E and vitamin C in different treatment schedules were evaluated for their antiemetic activity against cisplatin-induced emesis in dogs. While cisplatin-induced emesis was significantly reduced by all these agents, glutathione, MPG and combination of vitamin E and vitamin C produced maximum reduction. The antiemetic activity of antioxidants may be attributable to their ability to react with free radicals generated by cisplatin. The present study provides further evidence that free radicals play a role in cancer chemotherapy induced emesis and warrant clinical evaluation.
抗氧化剂，如谷胱甘肽、N-(2-巯基丙酰基)甘氨酸 (MPG)、维生素 E、维生素 C 和维生素 E 与维生素 C 的联合用药，在不同的治疗方案中，均被评估了其对顺铂诱导的犬呕吐的止吐活性。虽然所有这些药物都显著降低了顺铂诱导的呕吐，但谷胱甘肽、MPG 和维生素 E 与维生素 C 的联合用药产生了最大的降低效果。抗氧化剂的止吐活性可能归因于它们与顺铂产生的自由基反应的能力。本研究进一步证明，自由基在癌症化疗引起的呕吐中起作用，值得临床评估。
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