Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi-110 029, India.
Environ Toxicol Pharmacol. 1997 Feb 15;3(1):41-6. doi: 10.1016/s1382-6689(96)00137-8.
Cisplatin causes severe nausea and vomiting and also suppresses gastric emptying. Antioxidants have been shown to exert antiemetic effects against cisplatin induced emesis. In the present study, the effect of antioxidants-glutathione, N-2-(mercaptopropionyl)glycine (tiopronin), vitamin E, vitamin C and a combination of vitamin E and vitamin C was investigated against cisplatin induced delay in gastric emptying, in a rat model. Pretreatment with these antioxidants significantly reversed the cisplatin induced delay in gastric emptying. This effect of antioxidants may help in the improvement of other accompanying gastrointestinal symptoms such as abdominal discomfort and also contribute to their antiemetic efficacy against cytotoxic drugs.
顺铂会引起严重的恶心和呕吐，并且还会抑制胃排空。抗氧化剂已被证明对顺铂引起的呕吐具有止吐作用。在本研究中，研究了抗氧化剂-谷胱甘肽、N-2-(巯基丙酰基)甘氨酸（tiopronin）、维生素 E、维生素 C 以及维生素 E 和维生素 C 的组合对顺铂引起的大鼠胃排空延迟的影响。这些抗氧化剂的预处理显著逆转了顺铂引起的胃排空延迟。抗氧化剂的这种作用可能有助于改善其他伴随的胃肠道症状，如腹部不适，并且有助于它们对抗细胞毒性药物的止吐功效。
