Environ Toxicol Pharmacol. 1996 Oct 15;2(2-3):111-3. doi: 10.1016/S1382-6689(96)00039-7.
Under the Canadian Environmental Protection Act (CEPA), assessments have been completed for 44 environmental contaminants on the first Priority Substances List. The principles developed for the assessment of risk to human health for Priority Substances under CEPA are outlined, with specific emphasis on variations in exposure and response. These include the estimation of total exposure from all media, the development of exposure potency indices for carcinogens in lieu of low dose risk estimates and incorporation of toxicokinetic and toxicodynamic data, where available, to modify traditionally adopted uncertainty factors for development of tolerable intakes, or concentrations, for non-neoplastic effects.
根据《加拿大环境保护法》（CEPA），已对优先物质清单上的 44 种环境污染物完成了评估。本文概述了 CEPA 中用于评估优先物质对人类健康风险的原则，并特别强调了暴露和反应的变化。这些原则包括从所有介质中估算总暴露量、为致癌物质开发暴露效力指数以替代低剂量风险估计以及在可用时纳入毒代动力学和毒效动力学数据，以修改传统上采用的不确定性因素，从而制定可耐受摄入量或非肿瘤效应浓度。
