Department of Laboratory Medicine, Mie University School of Medicine, 2-174, Edobashi, Tsu, Mie 514, Japan.
Environ Toxicol Pharmacol. 1996 Dec 20;2(4):301-6. doi: 10.1016/s1382-6689(96)00061-0.
The herbal medicine, Sho-saiko-to (TJ-9), has been widely prescribed to chronic viral liver disease patients in Japan. This study examined the inductions of such sytokines as interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and granulocyte-colony stimulating factor (G-CSF), on some fractions of peripheral blood mononuclear cells (PBMC) by TJ-9 and each of its seven components. IL-1β, TNF-α, and G-CSF were highly induced by scutellaria root and glycyrrhiza root on monocytes/macrophages. By repeating the same experiments using taxol (an LPS antagonist)-treated substances, authors confirmed that these inductions were not attributable to the presence of quite low LPS in TJ-9 solution, and the cytokine inductions are the specific effect of TJ-9. Because TJ-9's macrobiotic effect in liver cirrhosis patients has been proven statistically in an etiological study, TJ-9 could be a new important therapy in chronic liver diseases.
中草药柴芍（TJ-9）在日本被广泛用于慢性病毒性肝病患者。本研究考察了 TJ-9 及其七种成分中的每一种对部分外周血单个核细胞（PBMC）的细胞因子白细胞介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）和粒细胞集落刺激因子（G-CSF）的诱导作用。在单核细胞/巨噬细胞上，黄芩根和甘草根可高度诱导产生 IL-1β、TNF-α 和 G-CSF。通过使用紫杉醇（LPS 拮抗剂）处理的物质重复相同的实验，作者证实这些诱导作用不是由于 TJ-9 溶液中存在相当低水平的 LPS，并且细胞因子的诱导作用是 TJ-9 的特异性作用。由于 TJ-9 在肝硬化患者中的生体疗效已在病因学研究中得到统计学证明，因此 TJ-9 可能成为慢性肝病的一种新的重要治疗方法。
