Sharma S S, Gupta Y K
Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
J Ethnopharmacol. 1998 Aug;62(1):49-55. doi: 10.1016/s0378-8741(98)00053-1.
Cisplatin causes nausea, vomiting and inhibition of gastric emptying. We have demonstrated the antiemetic effect of the acetone and ethanolic extract of ginger (Zingiber officinale, Roscoe, Zingiberacae) against cisplatin-induced emesis in dogs. In the present study, the acetone and 50% ethanolic extract of ginger in the doses of 100, 200 and 500 mg/kg (p.o.) and ginger juice, in the doses of 2 and 4 ml/kg, were investigated against cisplatin effect on gastric emptying in rats. All three ginger preparations significantly reversed cisplatin-induced delay in gastric emptying. The ginger juice and acetone extract were more effective than the 50% ethanolic extract. The reversal produced by the ginger acetone extract was similar to that caused by the 5-HT3 receptor antagonist ondansetron; however, ginger juice produced better reversal than ondansetron. Therefore, ginger, an antiemetic for cancer chemotherapy, may also be useful in improving the gastrointestinal side effects of cancer chemotherapy.
顺铂会引起恶心、呕吐并抑制胃排空。我们已经证明生姜（姜科植物姜，Roscoe）的丙酮提取物和乙醇提取物对顺铂诱导的犬呕吐具有止吐作用。在本研究中，研究了剂量为100、200和500mg/kg（口服）的生姜丙酮提取物和50%乙醇提取物以及剂量为2和4ml/kg的生姜汁对顺铂影响大鼠胃排空的作用。所有三种生姜制剂均能显著逆转顺铂诱导的胃排空延迟。生姜汁和丙酮提取物比50%乙醇提取物更有效。生姜丙酮提取物产生的逆转作用与5-HT3受体拮抗剂昂丹司琼引起的逆转作用相似；然而，生姜汁产生的逆转作用比昂丹司琼更好。因此，生姜作为癌症化疗的止吐药，可能也有助于改善癌症化疗的胃肠道副作用。
