Department of Pharmacology and Environmental Toxicology, Dr. A.L.M.Postgraduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India.
Environ Toxicol Pharmacol. 1999 Jul;7(3):189-97. doi: 10.1016/s1382-6689(99)00013-7.
In the present study, an investigation was undertaken to assess the protective efficacy in cadmium toxicity of vitamins administered simultaneously as well as post-treatment. Rats were treated with cadmium 1 mg/kg body weight (bw) powdered vitamin A chewable tablet 500 IU/kg bw/day and injectable vitamin D(3) (made into a suspension with gum tragacanth in 100 ml distilled water) 100 IU/kg bw/day, mixed with powdered pellet feed and fed to experimental animals. Spontaneous motor activity and Rota Rod Endurance time was recorded after both simultaneous (for 21 days) and post-treatment (42 days). Vitamin treated animals by themselves behaved like controls but attenuated the cadmium effect when given Cd simultaneously or as post-treatment. While the biochemical changes were assayed, vitamins which did not have any influence on their own, given simultaneously and as post-treatment, antagonized the cadmium effect on heart, liver tissues and serum. Both simultaneous and post-cadmium and -vitamin treatments significantly increased the activities of the enzymes aspartic amino transferase, alanine aminotransferase, acid phosphatase and alkaline phosphatase in tissues and serum. Simultaneous and post-vitamin treatment with Cd had an effect of bringing back the activity of the enzymes closer to control values. These data suggest that treatment with vitamin A and D can minimise the Cd effect when given to the population exposed to Cd.
在本研究中，我们调查了同时给予和治疗后给予维生素对镉毒性的保护作用。将大鼠用 1 毫克/千克体重（bw）的镉粉处理，每天给予 500 国际单位/千克 bw 的口服维生素 A 咀嚼片和 100 国际单位/千克 bw 的注射用维生素 D3（用刺梧桐树胶制成 100 毫升蒸馏水悬浮液），混合到粉末状颗粒饲料中，然后喂给实验动物。在同时（21 天）和治疗后（42 天）记录自发运动活动和转棒耐力时间。单独给予维生素的动物行为与对照组相似，但同时给予或作为治疗后给予时，可减轻镉的作用。在测定生化变化时，同时给予和治疗后给予对自身没有影响的维生素，拮抗了镉对心脏、肝脏组织和血清的影响。同时给予镉和维生素以及治疗后给予镉和维生素都显著增加了组织和血清中天冬氨酸氨基转移酶、丙氨酸氨基转移酶、酸性磷酸酶和碱性磷酸酶的活性。同时给予维生素 A 和 D 并给予镉治疗对恢复酶的活性有影响，使其接近对照值。这些数据表明，当人群暴露于镉时，给予维生素 A 和 D 治疗可以最小化镉的作用。
