Institute of Chemistry, University in Białystok, Al. Piłsudskiego 11/4, 15-443 Białystok, Poland.
Environ Toxicol Pharmacol. 1999 Dec;8(1):15-21. doi: 10.1016/s1382-6689(99)00024-1.
Methanol is oxidized in vivo to formaldehyde and then to formate and these processes are accompanied by free radicals generation. This paper reports the effect of antioxidants: trolox derivative (U-83836E) and N-acetylcysteine (NAC) on lipid peroxidation, surface charge density and hematological parameters of erythrocytes from rats intoxicated with methanol (3.0 g/kg body weight). Methanol administration caused increase in erythrocyte lipid peroxidation products and changes in surface charge density. Ingestion of methanol with U-83836E and NAC partially prevented these methanol-induced changes. This suggests that U83836E and NAC act as effective antioxidants and free radicals scavengers. They may have efficacy in protecting free radical damage to erythrocytes following methanol intoxication.
甲醇在体内被氧化为甲醛，然后再氧化为甲酸盐，这些过程伴随着自由基的生成。本文报道了抗氧化剂：trolox 衍生物（U-83836E）和 N-乙酰半胱氨酸（NAC）对甲醇（3.0 g/kg 体重）中毒大鼠红细胞的脂质过氧化、表面电荷密度和血液学参数的影响。甲醇的摄入导致红细胞脂质过氧化产物增加，表面电荷密度发生变化。同时摄入 U-83836E 和 NAC 可以部分预防这些由甲醇引起的变化。这表明 U83836E 和 NAC 是有效的抗氧化剂和自由基清除剂。它们可能在保护甲醇中毒后红细胞免受自由基损伤方面具有功效。
