Biotechnology and Molecular Biology Institute, CONICET-UNLP, La Plata, Argentina.
Neurosci Lett. 2011 Sep 1;501(3):163-6. doi: 10.1016/j.neulet.2011.07.007. Epub 2011 Jul 18.
Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. Galectin-3 (Gal-3) is an animal lectin that has been proposed to play an important role in some central nervous system (CNS) diseases. In this study, we analysed Gal-3 expression at the transcriptional and translational expression levels during JUNV-induced CNS disease. We found that Candid 1 strain induced, with relatively low mortality, a subacute/chronic CNS disease with significant glia activation and upregulation of Gal-3 in microglia cells as well as in reactive astrocytes that correlated with viral levels. Our results suggest an important role for Gal-3 in viral-induced CNS disease.
阿根廷出血热（AHF）是一种全身性发热综合征，其特征是几种血液学和神经系统改变，由 Junín 病毒（JUNV）引起，JUNV 是 Arenaviridae 科的一员。新生小鼠对 JUNV 高度易感，感染过程与所用病毒株有关。半乳糖凝集素-3（Gal-3）是一种动物凝集素，据报道其在一些中枢神经系统（CNS）疾病中发挥重要作用。在这项研究中，我们分析了 JUNV 诱导的中枢神经系统疾病过程中 Gal-3 在转录和翻译水平上的表达。我们发现，Candid 1 株以相对较低的死亡率诱导亚急性/慢性中枢神经系统疾病，伴有明显的神经胶质激活和小胶质细胞中 Gal-3 的上调，以及反应性星形胶质细胞中 Gal-3 的上调，与病毒水平相关。我们的结果表明 Gal-3 在病毒诱导的中枢神经系统疾病中起重要作用。
