Shandra A A, Godlevskiĭ L S, Mazarati A M, Nguyen T T
Fiziol Zh (1978). 1991 Mar-Apr;37(2):7-11.
Experiments on rats have shown that repeated administration of primarily subthreshold dose of picrotoxin leads to the occurrence and progressive enhancement of seizure manifestations. During picrotoxin kindling the decrease of locomotor activity in interictal periods was recorded. Microinjection of cerebrospinal fluid (CSF) of kindled rats into lateral brain ventriculi of recipients resulted in decrease of locomotor activity and acute primarily generalized picrotoxin induced seizures. These effects of CSF were blocked by naloxone administration and were observed only if injecting CSF which was preliminarily treated with protease inhibitors. It is concluded that endogenous opioid substances accumulate in CNS during kindling and evoke a decrease in the locomotor activity. These substances act as anticonvulsant factors which control the development of epileptic activity.
对大鼠的实验表明，反复给予主要为阈下剂量的印防己毒素会导致癫痫发作表现的出现和逐渐增强。在印防己毒素点燃过程中，记录到发作间期运动活动的减少。将点燃大鼠的脑脊液微注射到受体的侧脑室中，会导致运动活动减少以及急性主要全身性印防己毒素诱发的癫痫发作。脑脊液的这些作用可被纳洛酮给药阻断，并且只有在注射预先用蛋白酶抑制剂处理过的脑脊液时才会观察到。得出的结论是，内源性阿片类物质在点燃过程中在中枢神经系统中积累，并引起运动活动减少。这些物质作为抗惊厥因子控制癫痫活动的发展。
