Kryzhanovskiĭ G N, Shandra A A, Godlevskiĭ L S, Mazarati A M, Nguyen T T
Biull Eksp Biol Med. 1991 Mar;111(3):235-9.
It was shown in the experiments on rats that the repeated picrotoxin administration resulted in the kindling of generalized seizures. Generalized convulsions were followed by the development of either postictal depression or explosiveness. The injection of mu-opiate agonist met-enkephalin into hippocampus of kindled rats resulted in the increase in the severity of seizure reactions which were induced by picrotoxin and also in the increase in the number of animals with postictal explosiveness. The injection of dynorphin-A-1-13 (kappa-opiate agonist) into substantia nigra reticulata induced the locomotor depression which was like one in postictal period and resulted in the decrease of picrotoxin-induced seizures severity. It was concluded that mu-opiate system of hippocampus took part in the formation of generator of pathologically enhanced excitation in the structure during kindling and the development of seizure syndrome, providing also the postictal explosiveness. Kappa-opiate system of substantia nigra plays an important role in the activation of the antiepileptic system, limitation of seizures and the development of postictal depression.
在大鼠实验中表明，重复给予印防己毒素会导致全身性癫痫发作的点燃。全身性惊厥之后会出现发作后抑郁或爆发性。向点燃大鼠的海马体注射μ-阿片受体激动剂甲硫氨酸脑啡肽，会导致由印防己毒素诱发的癫痫反应严重程度增加，同时也会导致发作后有爆发性的动物数量增加。向黑质网状部注射强啡肽A-1-13（κ-阿片受体激动剂）会诱发类似发作后期的运动抑制，并导致印防己毒素诱发的癫痫严重程度降低。得出的结论是，海马体的μ-阿片系统在点燃过程中结构内病理性增强兴奋的发生器形成以及癫痫综合征的发展中发挥作用，同时也导致发作后爆发性。黑质的κ-阿片系统在抗癫痫系统的激活、癫痫发作的限制以及发作后抑郁的发展中起重要作用。
