Division of Neurology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 Rama 6 Road, Bangkok 10400, Thailand.
J Clin Neurosci. 2011 Oct;18(10):1333-5. doi: 10.1016/j.jocn.2011.01.028. Epub 2011 Jul 22.
Previous studies on the association between apolipoprotein E (APOE) alleles and Parkinson's disease (PD) have shown contradictory results. A recent study showed that APOE is involved in a molecular pathway of α-synuclein-induced neurodegeneration. We therefore conducted the first Thai study on APOE genotypes in patients with PD. We analysed the frequencies of APOE genotypes in our case-control study of 155 patients with sporadic PD and 158 control participants. We identified a higher frequency of the APOE-ε2 allele among patients with PD than among controls (odds ratio=2.309, 95% confidence interval=1.111-4.799). Genetic association is a powerful tool for detecting disease susceptibility alleles, but there are many pitfalls to consider before claiming any association. The discrepancy among the results of the genetic association studies of APOE genotypes as a risk of susceptibility to PD emphasises that this association merits clarification by the study of a single large homogeneous population.
先前有关载脂蛋白 E (APOE) 等位基因与帕金森病 (PD) 之间关联的研究结果相互矛盾。最近的一项研究表明，APOE 参与了α-突触核蛋白诱导的神经退行性变的分子途径。因此，我们进行了第一项针对泰国 PD 患者 APOE 基因型的研究。我们分析了 155 例散发性 PD 患者和 158 例对照参与者病例对照研究中 APOE 基因型的频率。我们发现 PD 患者中 APOE-ε2 等位基因的频率高于对照组（比值比=2.309，95%置信区间=1.111-4.799）。遗传关联是检测疾病易感等位基因的有力工具，但在声称任何关联之前，需要考虑许多陷阱。APOE 基因型作为 PD 易感性风险的遗传关联研究结果之间的差异强调了这一关联需要通过对单一大型同质人群的研究来阐明。
