TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, Netherlands; WUR/TNO Centre for Food Toxicology, PO Box 8000, 6700 EA Wageningen, Netherlands.
Environ Toxicol Pharmacol. 2001 Sep;10(4):141-52. doi: 10.1016/s1382-6689(01)00077-1.
This review summarizes current knowledge on glutathione (GSH) associated cellular processes that play a central role in defense against oxidative stress. GSH itself is a critical factor in maintaining the cellular redox balance and has been demonstrated to be involved in regulation of cell signalling and repair pathways. Enhanced expression of various enzymes involved in GSH metabolism, including glutathione peroxidases, γ-glutamyl cysteinyl synthetase (γ-GCS), glutathione S-transferases (GST) and membrane proteins belonging to the ATP-binding cassette family, such as the multidrug resistance associated protein, have all been demonstrated to play a prominent role in cellular resistance towards oxidative stress. This review stresses the fact that aco-ordinateinterplay between these systems is essential for efficient protection against oxidative stress.
本文综述了与谷胱甘肽（GSH）相关的细胞过程的最新知识，这些过程在对抗氧化应激中起着核心作用。GSH 本身是维持细胞氧化还原平衡的关键因素，已被证明参与细胞信号转导和修复途径的调节。增强各种参与 GSH 代谢的酶的表达，包括谷胱甘肽过氧化物酶、γ-谷氨酰半胱氨酸合成酶（γ-GCS）、谷胱甘肽 S-转移酶（GST）和属于三磷酸腺苷结合盒家族的膜蛋白，如多药耐药相关蛋白，都已被证明在细胞对氧化应激的抵抗中发挥重要作用。本文强调了这样一个事实，即这些系统之间的协调相互作用对于有效对抗氧化应激是必不可少的。
