Gérard-Monnier D, Chaudiere J
Centre de Recherche Bioxytech, OXIS International, Bonneuil-Sur-Marne, France.
Pathol Biol (Paris). 1996 Jan;44(1):77-85.
Glutathione (gamma-glutamyl-cysteinyl-glycine or GSH) is a cysteine-containing tripeptide with reducing and nucleophilic properties which play an important role in cellular protection from oxidative damage of lipids, proteins and nucleic acids. GSH regulates the metabolism of proteins and their activities by means of thiol-disulfide exchange. During oxidative stress, GSH plays a key role of protection and detoxification as a cofactor of glutathione peroxidases and glutathione-S-transferases. There are synergistic interactions between GSH and other components of the antioxidant defense system such as vitamin C, vitamin E and superoxide dismutases.
谷胱甘肽（γ-谷氨酰-半胱氨酰-甘氨酸或GSH）是一种含半胱氨酸的三肽，具有还原性和亲核性，在细胞保护免受脂质、蛋白质和核酸氧化损伤方面发挥重要作用。谷胱甘肽通过硫醇-二硫键交换调节蛋白质的代谢及其活性。在氧化应激期间，谷胱甘肽作为谷胱甘肽过氧化物酶和谷胱甘肽-S-转移酶的辅因子，发挥关键的保护和解毒作用。谷胱甘肽与抗氧化防御系统的其他成分如维生素C、维生素E和超氧化物歧化酶之间存在协同相互作用。
