Departments of Social and Preventive Medicine and Pharmacology and Toxicology, University at Buffalo, State of New York, Buffalo, NY 14214, USA.
Environ Toxicol Pharmacol. 2002 Sep;12(2):83-92. doi: 10.1016/s1382-6689(02)00026-1.
Consumption of PCB-contaminated sport fish from Lake Ontario has been reported to be associated with diminished female fecundity. To identify Polychlorinated biphenyl (PCB) congeners and other pesticides that might be associated with reduced fecundity, we followed 102 women aged 20-34 years attempting pregnancy who completed daily diaries for 12 at risk menstrual cycles. Fecundity referred to time-to-pregnancy (TTP) or the number of at risk menstrual cycles required for pregnancy. Blood specimens were obtained for 88 (86%) women and were analyzed using gas chromatography and electron capture for 66 PCB congeners and seven pesticides. Laboratory values were recovery, background and fat corrected prior to natural log transformation. Using stepwise discriminant analysis, congeners IUPAC #205 and #206 and hexaclorobenzene were significantly and positively associated with increasing TTP when women were categorized as becoming pregnant in the first or first three at risk menstrual cycles, respectively. Congeners #205 and #206 are reported to have (anti) estrogenic structural activity.
据报道，食用安大略湖受多氯联苯（PCB）污染的运动鱼类与女性生育能力下降有关。为了确定与生育能力下降相关的多氯联苯同系物和其他农药，我们对 102 名年龄在 20-34 岁之间、试图怀孕的女性进行了随访，这些女性在 12 个高危月经周期内每天完成日记。生育力是指怀孕所需的时间（TTP）或高危月经周期的数量。对 88 名（86%）女性进行了血液样本采集，并使用气相色谱法和电子捕获法对 66 种多氯联苯同系物和 7 种农药进行了分析。实验室值在自然对数转换之前进行了回收率、背景和脂肪校正。使用逐步判别分析，当女性在第一个或前三个高危月经周期内怀孕时，分别将 IUPAC#205 和#206 同系物和六氯苯归类为与 TTP 增加呈正相关。据报道，同系物#205 和#206 具有（抗）雌激素结构活性。
