Buck G M, Sever L E, Mendola P, Zielezny M, Vena J E
Department of Social and Preventive Medicine, State University of New York at Buffalo 14214, USA.
Am J Epidemiol. 1997 Dec 1;146(11):949-54. doi: 10.1093/oxfordjournals.aje.a009221.
Sport fish from the Great Lakes are contaminated with halogenated organics, heavy metals, and pesticides, thus serving as a route of exposure for fish-consuming populations. These contaminants are recognized reproductive toxicants in animals; few human studies are available. The purpose of this study was to assess consumption of contaminated fish in relation to time-to-pregnancy (TTP) among women in the New York State Angler Cohort. In 1993, structured telephone interviews were conducted with 2,445 of 2,977 (82%) female cohort members aged 18-40 years who stated upon enrollment in the cohort in 1991 that they were considering pregnancy over the next 3 years. Among the 1,234 women who reported being pregnant, 874 (71%) had a known TTP and comprise the study sample. After descriptive analyses, log transformations of the number of years of fish consumption (duration) and TTP were performed and entered into multiple regression models that also included other covariates. Duration of fish consumption and maternal age accounted for only a small percentage of the explained variance in TTP (R2 = 0.005), even after the analysis was restricted to women who reported eating fish (R2 = 0.006). All beta coefficients were positive. These preliminary findings do not support an adverse effect of contaminated fish consumption on TTP.
来自五大湖的游钓鱼类受到卤代有机物、重金属和农药的污染，从而成为食用鱼类人群的一个暴露途径。这些污染物在动物中被公认为生殖毒性物质；关于人类的研究很少。本研究的目的是评估纽约州垂钓者队列中女性食用受污染鱼类与怀孕时间（TTP）之间的关系。1993年，对2977名年龄在18至40岁的女性队列成员中的2445人（82%）进行了结构化电话访谈，这些女性在1991年加入队列时表示她们在未来3年内考虑怀孕。在报告怀孕的1234名女性中，874人（71%）有已知的怀孕时间，构成了研究样本。在进行描述性分析后，对鱼类食用年限（持续时间）和怀孕时间进行对数转换，并将其纳入多元回归模型，该模型还包括其他协变量。即使在分析仅限于报告食用鱼类的女性后（R2 = 0.006），鱼类食用持续时间和产妇年龄在解释怀孕时间的方差中所占比例也很小（R2 = 0.005）。所有的β系数都是正的。这些初步发现不支持食用受污染鱼类对怀孕时间有不利影响。
