Mendola P, Buck G M, Sever L E, Zielezny M, Vena J E
Department of Social and Preventive Medicine, State University of New York at Buffalo 14214, USA.
Am J Epidemiol. 1997 Dec 1;146(11):955-60. doi: 10.1093/oxfordjournals.aje.a009222.
Highly contaminated Lake Ontario sport fish represent an important human dietary exposure to polychlorinated biphenyls (PCBs) and other toxic contaminants that may disrupt endocrine pathways. New York State Angler Cohort women interviewed by telephone in 1993 provided menstrual cycle length (n = 2,223). Fish consumption at cohort enrollment in 1991 was categorized by duration and frequency and was used to calculate a PCB exposure index. Multiple regression analyses identified significant cycle length reductions with consumption of more than one fish meal per month (1.11 days) and moderate/high estimated PCB index (-1.03 days). Women who consumed contaminated fish for 7 years or more also had shorter cycles (-0.63 days).
安大略湖受高度污染的食用鱼是人类饮食中多氯联苯（PCBs）和其他可能干扰内分泌途径的有毒污染物的重要暴露源。1993年通过电话采访的纽约州垂钓者队列中的女性提供了月经周期长度（n = 2223）。1991年队列入组时的鱼类消费量按持续时间和频率分类，并用于计算多氯联苯暴露指数。多元回归分析发现，每月食用超过一顿鱼餐（减少1.11天）和中度/高度估计多氯联苯指数（减少1.03天）会使周期长度显著缩短。食用受污染鱼类7年或更长时间的女性周期也较短（减少0.63天）。
