Department of Public Health, University of Szeged, Dóm tér 10, H-6720 Szeged, Hungary.
Environ Toxicol Pharmacol. 2003 Apr;13(3):181-6. doi: 10.1016/S1382-6689(02)00160-6.
Male Wistar rats were treated for 4, 8 and 12 weeks with 3.5, 7.0 or 14.0 mg/kg cadmium (in the form of cadmium chloride) by gavage. Changes induced in certain electrophysiological parameters-electrocorticogram frequency; latency and duration of cortical sensory evoked potentials; conduction velocity and relative and absolute refractory periods of a peripheral nerve-were analyzed. On the electrocorticogram, increased frequency was seen. Lengthened latency and duration of the cortical evoked potentials, as well as lowered conduction velocity and increased refractory periods in the peripheral nerve, were observed. These changes seemed to increase with the dose and the treatment time and were statistically significant mainly in the highest dose groups following 12 weeks of treatment. The results show that subchronic, low-level exposure by cadmium affects the rat's spontaneous and evoked bioelectric activity and point at the possible consequences in exposed humans.
雄性 Wistar 大鼠通过灌胃接受为期 4、8 和 12 周的 3.5、7.0 或 14.0mg/kg 剂量的镉（以氯化镉的形式）处理。分析了某些电生理参数（脑电频率；皮质感觉诱发电位的潜伏期和持续时间；外周神经的传导速度以及相对和绝对不应期）的变化。在脑电上，观察到频率增加。皮质诱发电位的潜伏期和持续时间延长，以及外周神经的传导速度降低和不应期延长，这些变化似乎随着剂量和治疗时间的增加而增加，并且在治疗 12 周后主要在最高剂量组中具有统计学意义。结果表明，亚慢性、低水平的镉暴露会影响大鼠的自发和诱发生物电活动，并指出了暴露于人类的可能后果。
