城市工人淋巴细胞-单核细胞对外来血球凝集素的反应。
Response of lympho-monocytes to phytohemagglutinin in urban workers.
机构信息
Department of Occupational Medicine, University of Rome "La Sapienza", Via Monte delle Gioie No. 13, 00199 Rome, Italy.
出版信息
Environ Toxicol Pharmacol. 2004 May;17(1):13-8. doi: 10.1016/j.etap.2004.01.004.
The aim of this study is to evaluate whether traffic police exposed to urban pollutants could be at risk of changes on proliferative response of blood lympho-monocytes to the mitogen phytohemagglutinin (PHA) compared to a control group. Traffic police were matched with controls by sex, age, length of service, drinking habits and smoking habits after excluding main confounding factors. So, 77 traffic police exposed to urban pollutants (43 men and 34 women) and 77 controls with indoor activity (43 men and 34 women) were included in the study. The proliferative response of blood lympho-monocytes to the mitogen PHA was significantly lower in male and female traffic police compared to controls (respectively, P=0.000 and 0.014). The possibility of an effect on immune system and therefore on the blood lympho-monocytes proliferative answer in traffic police exposed to urban pollutants, can be assumed.
本研究旨在评估接触城市污染物的交通警察是否存在血淋巴单核细胞对植物血凝素（PHA）有丝分裂原增殖反应发生变化的风险，与对照组相比。交通警察通过性别、年龄、工龄、饮酒习惯和吸烟习惯与对照组相匹配，排除主要混杂因素后，共纳入 77 名接触城市污染物的交通警察（43 名男性和 34 名女性）和 77 名室内活动对照者（43 名男性和 34 名女性）。与对照组相比，男性和女性交通警察的血淋巴单核细胞对植物血凝素有丝分裂原的增殖反应明显降低（分别为 P=0.000 和 0.014）。可以假设接触城市污染物的交通警察的免疫系统，因此对血液淋巴单核细胞增殖反应有影响的可能性。
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