Department of Anthropology, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA; Department of Epidemiology, School of Public Health, University at Albany, State University of New York, 1400 Washington Avenue, Albany, NY 12222, USA.
Environ Toxicol Pharmacol. 2004 Nov;18(2):91-9. doi: 10.1016/j.etap.2004.01.010.
The effects of endocrine disrupting environmental contaminants such as polychlorinated biphenyls (PCBs), hexachlorobenzene (HCB), p,p'-dichlorophenyldichloroethylene (p,p'-DDE), mirex, and lead, are examined in a sample of youth of the Akwesasne Mohawk Nation who are 10-16.9 years of age (n=115). The Akwesasne community is located adjacent to hazardous waste sites where PCBs and other toxicants have contaminated the local ecology. This study examines the relationship between measures of thyroid function and endocrine disrupting environmental toxicants. Both with and without statistical adjustment for other toxicants, as well as age, sex and lipid levels, several indicators of PCB burden are significantly, negatively related to levels of free thyroxine and total thyroxine, and positively to thyrotropin. Lead level was positively related to triidothyronine. Future testing of non-linear relationships is warranted. Despite the linear associations with thyrotropin, free and total thyroxine, PCBs were not related to increased occurrence of these hormones outside the clinically normal range for the testing laboratory.
研究人员检测了在年龄为 10-16.9 岁的阿克瓦萨斯内莫霍克族青年（n=115）体内，内分泌干扰环境污染物（如多氯联苯、六氯苯、p,p'-二氯二苯二氯乙烯、灭蚁灵和铅）的影响。阿克瓦萨斯内社区毗邻危险废物堆放场，多氯联苯和其他有毒物质污染了当地生态系统。本研究探讨了甲状腺功能和内分泌干扰环境毒物之间的关系。在不考虑其他毒物、年龄、性别和脂质水平的情况下，以及在对这些因素进行统计调整后，几种多氯联苯负荷指标与游离甲状腺素和总甲状腺素水平呈显著负相关，与促甲状腺激素呈正相关。铅水平与三碘甲状腺原氨酸呈正相关。未来需要进一步测试非线性关系。尽管与促甲状腺激素、游离甲状腺素和总甲状腺素呈线性关联，但多氯联苯与检测实验室临床正常范围内这些激素的异常发生率增加无关。
