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钛表面亲水改性纳米羟基磷灰石涂层的抗菌和促成骨性能。

Antimicrobial and osteogenic properties of a hydrophilic-modified nanoscale hydroxyapatite coating on titanium.

机构信息

Department of Oral Biomaterials and Technology, Showa University School of Dentistry, Tokyo, Japan.

出版信息

Nanomedicine. 2012 Apr;8(3):374-82. doi: 10.1016/j.nano.2011.07.001. Epub 2011 Jul 23.

Abstract

Hydroxyapatite (HA)-coated titanium (Ti) is commonly used for implantable medical devices. This study examined in vitro osteoblast gene expression and antimicrobial activity against early and late colonizers of supra-gingival plaque on nanoscale HA-coated Ti prepared by discharge in a physiological buffered solution. The HA-coated Ti surface showed super-hydrophilicity, whereas the densely sintered HA and Ti surfaces alone showed lower hydrophilicity. The sintered HA and HA-coated Ti surfaces enhanced osteoblast phenotypes in comparison with the bare Ti surface. The HA-coated Ti enabled antimicrobial activity against early colonizers of supra-gingival plaques, namely Streptococcus mitis and Streptococcus gordonii. Such antimicrobial activity may be caused by the surface hydrophilicity, thereby leading to a repulsion force between the HA-coated Ti surface and the bacterial cell membranes. On the contrary, the sintered HA sample was susceptible to infection of microorganisms. Thus, hydrophilic-modified HA-coated Ti may have potential for use in implantable medical devices. From the Clinical Editor: This study establishes that Hydroxyapatite (HA)-coated titanium (Ti) surface of implanted devices may result in an optimal microenvironment to control and prevent infections and may have potential future clinical applications.

摘要

羟基磷灰石(HA)涂层钛(Ti)常用于植入式医疗器械。本研究通过在生理缓冲溶液中放电制备纳米级 HA 涂层 Ti,考察了其对龈上菌斑早期和晚期定植菌的体外成骨细胞基因表达和抗菌活性。HA 涂层 Ti 表面呈现超亲水性,而致密烧结的 HA 和 Ti 表面则亲水性较低。与裸 Ti 表面相比,烧结 HA 和 HA 涂层 Ti 表面增强了成骨细胞表型。HA 涂层 Ti 对龈上菌斑的早期定植菌(即变形链球菌和戈登链球菌)具有抗菌活性。这种抗菌活性可能是由表面亲水性引起的,从而导致 HA 涂层 Ti 表面与细菌细胞膜之间产生排斥力。相反,烧结 HA 样品易受微生物感染。因此,亲水改性的 HA 涂层 Ti 可能具有在植入式医疗器械中的应用潜力。从临床编辑的角度来看:这项研究表明,植入设备的羟基磷灰石(HA)涂层钛(Ti)表面可能会产生一个优化的微环境,以控制和预防感染,并可能具有潜在的临床应用前景。

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