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探索γ射线辅助羟基磷灰石及其与纳米纤维素和壳聚糖制备的复合材料的生物医学性能。

Exploring the biomedical competency of gamma-radiation aided hydroxyapatite and its composite fabricated with nano-cellulose and chitosan.

作者信息

Sahadat Hossain Md, Shaikh Md Aftab Ali, Jahan Shirin Akter, Mahmud Monika, Bin Mobarak Mashrafi, Rahaman Md Saifur, Uddin Md Najem, Ahmed Samina

机构信息

Institute of Glass and Ceramic Research and Testing (IGCRT), Bangladesh Council of Scientific and Industrial Research (BCSIR) Dr Qudrat-i-Khuda Road, Dhanmondi Dhaka-1205 Bangladesh

Bangladesh Council of Scientific and Industrial Research (BCSIR) Dr Qudrat-i-Khuda Road, Dhanmondi Dhaka-1205 Bangladesh

出版信息

RSC Adv. 2023 Mar 27;13(14):9654-9664. doi: 10.1039/d3ra00476g. eCollection 2023 Mar 20.

DOI:10.1039/d3ra00476g
PMID:36994085
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10041542/
Abstract

The well-known biomaterial Ca-hydroxyapatite (Hap) in its pristine form holds the top ranking position in the field of biomedical research and extensive investigation is continuing across the globe to enhance its competency. Hence, having the intention to introduce superior physiognomies ( cytotoxicity, haemocompatibility, and bioactivity coupled with antimicrobial and antioxidant activity) in Hap, in this research work, we exposed Hap to 200 kGy γ-radiation. As a result, γ-radiated Hap exhibited extreme antimicrobial (more than 98%) and moderate (∼34%) antioxidant properties. On the other hand, cytotoxicity and haemocompatibility of γ-radiated Hap were in good agreement with the ISO 10993-5 and ISO 10993-4 standards respectively. Since, bone and joint infections as well as degenerative disorders osteoarthritis, osteomyelitis, bone injury, and spinal problems have emerged as serious issues and urge a remedial way out, application of γ-radiated Hap could be a promising solution in this regard.

摘要

著名的生物材料钙羟基磷灰石（Hap）以其原始形式在生物医学研究领域占据首要地位，全球范围内正在进行广泛研究以提高其性能。因此，为了在Hap中引入卓越的特性（细胞毒性、血液相容性以及生物活性，并兼具抗菌和抗氧化活性），在本研究工作中，我们将Hap暴露于200 kGy的γ辐射下。结果，γ辐射后的Hap表现出极强的抗菌性能（超过98%）和中等程度（约34%）的抗氧化性能。另一方面，γ辐射后Hap的细胞毒性和血液相容性分别与ISO 10993-5和ISO 10993-4标准相符。由于骨与关节感染以及退行性疾病（骨关节炎、骨髓炎、骨损伤和脊柱问题）已成为严重问题并迫切需要补救方法，γ辐射后Hap的应用在这方面可能是一个有前景的解决方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/ebbdafa8dd6c/d3ra00476g-f11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/344bf979446a/d3ra00476g-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/cb25b111a47c/d3ra00476g-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/d52f1552d56d/d3ra00476g-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/1d6abd558af4/d3ra00476g-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/16d0291bb6c9/d3ra00476g-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/4aeed4c3a18f/d3ra00476g-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5149/10041542/ebbdafa8dd6c/d3ra00476g-f11.jpg

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Preparation and characterization of highly crystalline hydroxyapatite (HAp) from the scales of an anadromous fish (): a comparative study with the freshwater fish scale () derived HAp.

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[2]
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[3]
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[4]
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[5]
Synthesis and Characterization of Nano-Hydroxyapatite Obtained from Eggshell via the Hydrothermal Process and the Precipitation Method.

Molecules. 2023-6-22

本文引用的文献

[1]
Synthesis and characterization of rod-like amino acids/nanohydroxyapatite composites to inhibit osteosarcoma.

RSC Adv. 2022-12-16

[2]
Fluorescence control of chitin and chitosan fabricated surface functionalization using direct oxidative polymerization.

RSC Adv. 2018-2-13

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Biomaterials for bone tissue engineering scaffolds: a review.

RSC Adv. 2019-8-21

[4]
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RSC Adv. 2020-1-22

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Synthesis and characterizations of natural limestone-derived nano-hydroxyapatite (HAp): a comparison study of different metals doped HAps on antibacterial activity.

RSC Adv. 2021-4-28

[6]
UV-assisted synthesis of hydroxyapatite from eggshells at ambient temperature: cytotoxicity, drug delivery and bioactivity.

RSC Adv. 2021-1-19

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Redispersible polymer powder modified cementitious tile adhesive as an alternative to ordinary cement-sand grout.

Heliyon. 2021-11-17

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Pure hydroxyapatite synthesis originating from amorphous calcium carbonate.

Sci Rep. 2021-6-2

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Gamma sterilization of collagen/hydroxyapatite composites: Validation and radiation effects.

Appl Radiat Isot. 2021-8

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