Department of Psychology, University of North Dakota, Grand Forks, ND 58202-8380, USA.
Physiol Behav. 2011 Oct 24;104(5):1048-52. doi: 10.1016/j.physbeh.2011.07.006. Epub 2011 Jul 18.
Ames dwarf mice have a Prop-1 mutation that has been identified with increased levels of IGF-I in the central nervous system, upregulation of neuroprotective systems, and increased lifespan. To elucidate the behavioral effects of the Prop-1 mutation, 8 Ames dwarf and 7 normal mice (all of whom were 8 months of age or younger) were compared on a differential-reinforcement-of-low-rate-of-responding schedule of reinforcement and a matching-to-sample task. On both tasks, nosepokes were reinforced with access to a saccharin solution. Comparisons were based on several measures of behavioral efficiency: pause durations, intertrial intervals, and numbers of responses. Ames dwarf mice were generally less efficient than normal mice. One possible cause of this outcome is that relatively young Ames dwarf mice show less cognitive development than age-matched normal mice.
艾姆斯矮小鼠存在 Prop-1 突变，这导致其中枢神经系统中的 IGF-I 水平升高、神经保护系统上调以及寿命延长。为了阐明 Prop-1 突变的行为影响，我们将 8 只艾姆斯矮小鼠和 7 只正常小鼠（均为 8 个月或更小）进行比较，比较内容为差异强化低反应率强化程序和匹配样本任务。在这两个任务中，鼻触都可以获得蔗糖溶液作为奖励。比较是基于几个行为效率的指标：停顿时间、试验间间隔和反应次数。艾姆斯矮小鼠通常比正常小鼠效率低。这种结果的一个可能原因是，相对年轻的艾姆斯矮小鼠的认知发育不如年龄匹配的正常小鼠。
