Scuola Europea di Medicina Molecolare (SEMM), Campus IFOM-IEO, Via Adamello 16, 20139 Milan, Italy.
Microbes Infect. 2011 Nov;13(12-13):983-91. doi: 10.1016/j.micinf.2011.06.011. Epub 2011 Jul 7.
The immune system, to protect the body, must discriminate between the pathogenic and non-pathogenic microbes and respond to them in different ways. How the mucosal immune system manages to make this distinction is poorly understood. We suggest here that the distinction between pathogenic and non-pathogenic microbes is made by an integrated system rather than by single types of cells or single types of receptors; a systems biology approach is needed to understand immune recognition.
免疫系统为了保护机体，必须区分病原性和非病原性微生物，并以不同的方式对它们作出反应。然而，黏膜免疫系统如何能够作出这种区分尚不清楚。我们在此提出，病原性和非病原性微生物的区分是通过一个整合的系统而不是通过单一类型的细胞或单一类型的受体来实现的；需要采用系统生物学方法来理解免疫识别。
