National Veterinary and Food Research Institute, Oulu Regional Unit, P.O. Box 517, FIN-90101 Oulu, Finland.
Environ Toxicol Pharmacol. 2005 Jan;19(1):139-52. doi: 10.1016/j.etap.2004.06.001.
A thiamine deficiency disease termed M74 syndrome affects the yolk-sac fry of wild and feral Baltic salmon. However, very little is known about the pharmacokinetics of thiamine in salmon. This study examined the pharmacokinetics of thiamine hydrochloride injected intraperitoneally into feral and farmed Baltic salmon females preparing for spawning. The total thiamine concentrations in the eggs and white muscle of feral females were only half of those in the farmed fish after injection. The relative inefficiency of the incorporation of thiamine into the eggs in feral Baltic salmon may be a predisposition factor for M74 syndrome. The relative bioavailability of intraperitoneally-injected thiamine hydrochloride was shown to be ca. 94% of that administered intra-aortically. A far lower intraperitoneal dose (ca. 20mgkg(-1) fish) than currently used was shown to elevate the total thiamine concentration in the eggs above the critical threshold of M74 syndrome.
一种称为 M74 综合征的硫胺素缺乏症影响野生和野生波罗的海三文鱼的卵黄囊鱼苗。然而，关于三文鱼中硫胺素的药代动力学知之甚少。本研究检查了准备产卵的野生和养殖波罗的海三文鱼雌性经腹腔注射盐酸硫胺素的药代动力学。注射后，野生雌鱼卵和白肌中的总硫胺素浓度仅为养殖鱼类的一半。野生波罗的海三文鱼中硫胺素掺入卵中的相对效率低下可能是 M74 综合征的易患因素。腹腔内注射盐酸硫胺素的相对生物利用度约为主动脉内给药的 94%。结果表明，远低于目前使用的腹腔内剂量（约 20mgkg(-1)鱼）可将卵中的总硫胺素浓度提高到 M74 综合征的临界阈值以上。
