Faculty of Paramedical Sciences, Arak University of Medical Sciences, Arak, Iran.
Environ Toxicol Pharmacol. 2005 Jul;20(1):88-91. doi: 10.1016/j.etap.2004.10.007. Epub 2004 Dec 8.
Free radicals play an important role in toxicity of pesticides and environmental chemicals. Organophosphorus insecticides (OPIs) may induce oxidative stress leading to generation of free radicals and alteration in antioxidant system. To complete the previous surveys, this study was conducted to evaluate the existence of oxidative stress, balance between total antioxidant capacity and oxygen free radicals in patients with acute OPI exposure. In this case control study, a total of 22 acute OPI poisoning patients were included and blood samples were analyzed for lipid peroxidation, total antioxidant capacity, total thiol groups, and cholinesterase levels. The results showed significant lipid peroxidation accompanied with decreased levels of total antioxidant capacity, total thiols, and cholinesterase activity. A significant correlation existed between cholinesterase depression and reduced total antioxidant capacity. It is concluded that oxygen free radicals and their related interactions like lipid peroxidation are present in acute OPI poisoning. Use of antioxidants may be beneficial in treatment of OPIs acute poisoning which remains to be elucidated by further clinical trials.
自由基在农药和环境化学物的毒性中起着重要作用。有机磷杀虫剂（OPIs）可能会诱导氧化应激，导致自由基的产生和抗氧化系统的改变。为了完成之前的调查，本研究旨在评估急性有机磷杀虫剂暴露患者是否存在氧化应激以及总抗氧化能力和氧自由基之间的平衡。在这项病例对照研究中，共纳入了 22 例急性有机磷杀虫剂中毒患者，并分析了其血液样本中的脂质过氧化、总抗氧化能力、总巯基和胆碱酯酶水平。结果显示，脂质过氧化显著增加，同时总抗氧化能力、总巯基和胆碱酯酶活性降低。胆碱酯酶抑制与总抗氧化能力降低之间存在显著相关性。结论：急性有机磷杀虫剂中毒患者存在氧自由基及其相关的相互作用，如脂质过氧化。抗氧化剂的使用可能对有机磷杀虫剂急性中毒的治疗有益，但这仍需要进一步的临床试验来阐明。
