Key Laboratory of Marine Ecology and Environmental Science, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; Graduate School of the Chinese Academy of Science, Beijing 100039, China.
Environ Toxicol Pharmacol. 2005 Nov;20(3):465-70. doi: 10.1016/j.etap.2005.05.006. Epub 2005 Jul 14.
Fish Lateolabrax japonicus were exposed to anion surfactant sodium dodecylbenzene sulfonate (SDBS) and sodium dodecyl sulfate (SDS) at 1mg/l, respectively, for 6, 12 and 18d, with one control group. Liver antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH) and glutathione S-transferase (GST) were determined; brain acetylcholinesterase (AChE) and liver inducible nitric oxide synthase (iNOS) activities were also measured. The results of the study indicated that these parameters made different, sometimes, adverse responses to SDBS and SDS exposure, such as the activity of iNOS can be inhibited by SDBS and induced by SDS, the different physico-chemical characteristics of SDBS and SDS should be responsible for their effects on enzyme activities.
将鲈鱼暴露于浓度为 1mg/L 的十二烷基苯磺酸钠（SDBS）和十二烷基硫酸钠（SDS）中，分别进行 6、12 和 18d 的染毒，设立一个对照组。测定肝脏抗氧化酶，包括超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GPx）、还原型谷胱甘肽（GSH）和谷胱甘肽 S-转移酶（GST）的活性；同时还测定了脑组织乙酰胆碱酯酶（AChE）和肝脏诱导型一氧化氮合酶（iNOS）的活性。研究结果表明，这些参数对 SDBS 和 SDS 的暴露有不同的，有时是不利的反应，如 iNOS 的活性可以被 SDBS 抑制，而被 SDS 诱导；SDBS 和 SDS 的不同物理化学特性可能是导致它们对酶活性影响的原因。
