Key Laboratory of Marine Ecology & Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.
Ecotoxicol Environ Saf. 2010 Jul;73(5):835-41. doi: 10.1016/j.ecoenv.2009.12.011. Epub 2009 Dec 31.
The effects of in vivo exposure of Mytilus galloprovincialis to two anionic surfactants (SDBS and SDS) on the molecular biomarker system were studied. After continuous exposure for 72 days, activities/levels of GST, GPx and GSH were significantly higher than in corresponding control groups following exposure to 3.000 mg/L SDS and SDBS. Activities of SOD and CAT were significantly inhibited by experimental SDBS (except CAT in 0.100mg/L group), but not by SDS. Statistical analysis of enzyme activities/levels suggested that there were significant positive relationships between GST and GPx, and negative relationships were found between GSH and CAT, GSH and SOD. Amplified fragment length polymorphism (AFLP) results showed that a greater genotoxic effect was observed for SDBS than for SDS. Based on the above results, the biomarker system of mussels can be affected by the two anionic surfactants (>or=3.000 mg/L); it was more easily affected by SDBS than by SDS.
研究了两种阴离子表面活性剂（SDBS 和 SDS）在活体暴露于贻贝（Mytilus galloprovincialis）后对分子生物标志物系统的影响。连续暴露 72 天后，暴露于 3000mg/L SDS 和 SDBS 的实验组中 GST、GPx 和 GSH 的活性/水平明显高于相应对照组。SOD 和 CAT 的活性受到实验 SDBS 的显著抑制（除 0.100mg/L 组的 CAT 外），但 SDS 没有。酶活性/水平的统计分析表明，GST 和 GPx 之间存在显著的正相关关系，GSH 和 CAT、GSH 和 SOD 之间存在显著的负相关关系。扩增片段长度多态性（AFLP）结果表明，SDBS 比 SDS 具有更大的遗传毒性作用。基于上述结果，两种阴离子表面活性剂（≥3000mg/L）会影响贻贝的生物标志物系统；SDBS 比 SDS 更容易受到影响。
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