Department of Biochemistry, University of Kerala, Kariavattom, Thiruvananthapuram, Kerala 695 581, India.
Environ Toxicol Pharmacol. 2005 Nov;20(3):471-7. doi: 10.1016/j.etap.2005.05.010. Epub 2005 Aug 1.
The partially purified petroleum ether extractable fraction of the whole plant Aerva lanata (PF) was evaluated for the protective effect against liver damage induced by carbon tetra chloride (CCl(4)) in Sprague Dawley rats. Rats were orally administered with PF (50 and 100mg/kg body weight) for 14 days before CCl(4) challenge and 100mg of PF alone for toxicity analysis without CCl(4) administration. The results showed that CCl(4) administration significantly damaged the liver as evident from histopathology and very high activity of serum and liver marker enzymes. It also reduced the antioxidant enzyme status of the animals. PF administration significantly reversed the histopathological changes and restored the elevated activities of liver marker enzymes and also enhanced the antioxidant enzyme activities. The extract also reduced hepatic lipid peroxidation and increased the serum total protein and albumin/globulin (A/G) ratio. Preliminary phytochemical analysis of PF showed the presence of alkaloids. These observations clearly indicate that PF contains antioxidant alkaloids capable of ameliorating the CCl(4)-induced hepatic injury by virtue of its antioxidant activity.
全草旋覆花（PF）的部分纯化石油醚可提取物部分，用于评价其对四氯化碳（CCl4）诱导的 Sprague Dawley 大鼠肝损伤的保护作用。大鼠在 CCl4 攻击前连续 14 天口服 PF（50 和 100mg/kg 体重），并单独给予 100mg PF 进行毒性分析而不给予 CCl4。结果表明，CCl4 给药显著损害肝脏，组织病理学和血清及肝脏标志物酶的非常高的活性可见一斑。它还降低了动物的抗氧化酶状态。PF 给药显著逆转了组织病理学变化，恢复了升高的肝标志物酶的活性，并增强了抗氧化酶的活性。提取物还降低了肝脂质过氧化，增加了血清总蛋白和白蛋白/球蛋白（A/G）比值。PF 的初步植物化学分析表明存在生物碱。这些观察结果清楚地表明，PF 含有抗氧化生物碱，能够通过其抗氧化活性减轻 CCl4 诱导的肝损伤。
