LPTC Toxicologie Biochimique, Université de Bordeaux 1, UMR CNRS 5472, avenue des facultés, 33405 Talence cedex, France.
Environ Toxicol Pharmacol. 2006 May;21(3):323-30. doi: 10.1016/j.etap.2005.10.007. Epub 2006 Jan 19.
Freshwater clams Corbicula fluminea were experimentally exposed to a range of tributyltin (TBT) (50, 250 and 500ng Sn/L) and 17β-estradiol (20, 200, 2000ng/L) for 30 days. After 15 and 30 days, phagocytosis activity of haemocytes and lysosomal structural changes in the digestive cells were assayed. 17β-Estradiol exerted a higher inhibition on phagocytosis than tributyltin. This would suggest the existence of estrogen receptors, influencing the immune function. The stereological parameters measured for lysosomal structural changes in animals exposed to tributyltin varied as observed in other studies. Tributyltin is then depurated as other contaminants via digestive cell lysosomal compartment. This experiment emphasized a possible approach on the influence of endocrine disrupting compounds on a hermaphroditic species for environmental surveys.
将淡水贝类圆田螺（Corbicula fluminea）暴露于一系列三丁基锡（TBT）（50、250 和 500ng Sn/L）和 17β-雌二醇（20、200、2000ng/L）中进行了 30 天的实验。在 15 天和 30 天后，测定了血细胞的吞噬活性和消化细胞中的溶酶体结构变化。17β-雌二醇对吞噬作用的抑制作用高于三丁基锡。这表明存在雌激素受体，影响免疫功能。暴露于三丁基锡的动物的溶酶体结构变化的体视学参数与其他研究中的观察结果不同。三丁基锡随后与其他污染物一样通过消化细胞溶酶体室被排泄。该实验强调了内分泌干扰化合物对环境调查中雌雄同体物种的影响的一种可能方法。
