Industrial Toxicology Research Centre, Post Box No. 80, M.G. Marg, Lucknow 226001, Uttar Pradesh, India.
Environ Toxicol Pharmacol. 2007 Mar;23(2):135-9. doi: 10.1016/j.etap.2006.07.012. Epub 2006 Aug 4.
In recent years controversy has evolved regarding the role of environmental pollutants especially chlorinated pesticides and heavy metals on male infertility. Previous data generated on the correlation of chlorinated pesticides with human semen are scarce and controversial. The objective is to explore the possibility of correlation if any between the chlorinated pesticides and sperm count and motility. Semen analysis were performed in 50 samples collected each from fertile and infertile men and pesticides estimation for dichlorodiphenyltrichloroethane (DDT) and its metabolites dichloro-2,2-bis(p-chlorophenyl) ethylene (DDE); 1,1,1-trichloro-2,2-bis(p-chlorophenyl ethane) (pp'DDT); 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (pp'DDD), 1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (op'DDT), aldrin, hexachlorocyclohexane (HCH) isomers alpha (α), beta (β), gamma (γ), delta (δ) were done by gas liquid chromatography. The higher concentrations of pesticide, viz. α-, β-, γ-, δ-HCH, DDT and its metabolites (pp'DDE and pp'DDD) were detected in semen samples of infertile males. The data showed significant association between β-HCH, γ-HCH, pp'DDE, pp'DDD with semen quality parameters.
近年来,环境污染物,特别是氯化农药和重金属对男性不育的作用引起了争议。以前关于氯化农药与人类精液相关性的数据很少且存在争议。目的是探讨氯化农药与精子计数和活力之间是否存在相关性。对 50 份来自生育能力正常和不育男性的精液样本进行了分析,并对二氯二苯三氯乙烷(DDT)及其代谢物二氯-2,2-双(对氯苯基)乙烯(DDE);1,1,1-三氯-2,2-双(对氯苯基)乙烷(pp'DDT);1,1-二氯-2,2-双(对氯苯基)乙烷(pp'DDD);1,1,1-三氯-2-(邻氯苯基)-2-(对氯苯基)乙烷(op'DDT)、艾氏剂、六氯环己烷(HCH)异构体 α(α)、β(β)、γ(γ)、δ(δ)进行了气相色谱分析。在不育男性的精液样本中检测到更高浓度的农药,即 α-、β-、γ-、δ-HCH、DDT 及其代谢物(pp'DDE 和 pp'DDD)。数据显示,β-HCH、γ-HCH、pp'DDE 和 pp'DDD 与精液质量参数之间存在显著关联。