Department of Zoology, Fish Reproductive Toxicology Laboratory, Tilak Dhari College, Jaunpur 222002, India.
Environ Toxicol Pharmacol. 2007 Nov;24(3):245-51. doi: 10.1016/j.etap.2007.06.001. Epub 2007 Jun 15.
Effects of 40 days of exposure and 20 days of recovery response at sublethal concentration of technical grades of gamma isomer of hexachlorocyclohexane (γ-HCH, 0.025ppm, 99.8%) and dichlorodiphenyltrichloroethane (DDT, 5.0ppm) in tissue (liver, brain and ovary) bioconcentrations, gonadosomatic index (GSI) and plasma levels of estradiol-17β (E2) have been estimated during prespawning phase in the catfish Heteropneustes fossilis (Bloch). The results indicated that the tissue bioconcentrations of both HCHs (HCH isomers) and DDTs (metabolites of DDT) in liver, brain and ovary were in preferential order (liver>brain>ovary). The GSI and plasma levels of E2 were declined in response to exposure of γ-HCH and DDT. On withdrawal of exposure of pesticide there was recovery of HCHs in exposed fish for all tissues studied, whereas DDTs exposed fish showed recovery only in liver. Recovery of E2 production was also recorded in γ-HCH exposed fish whereas very little recorded in DDT exposed fish. It is suggested that HCHs and DDTs have preferential order (liver>brain>ovary) of their tissue bioconcentrations and HCH/DDT-withdrawal-dependent recovery during studied phase.
在亚致死浓度下暴露 40 天和恢复 20 天技术级六氯环己烷（γ-HCH，0.025ppm，99.8%）和滴滴涕（DDT，5.0ppm）对组织（肝、脑和卵巢）生物浓度、性腺指数（GSI）和血浆中雌二醇-17β（E2）水平的影响在鲶鱼 Heteropneustes fossilis（Bloch）的产卵前阶段进行了估计。结果表明，两种 HCH（HCH 异构体）和 DDT（DDT 的代谢物）在肝、脑和卵巢中的组织生物浓度均按优先顺序排列（肝>脑>卵巢）。γ-HCH 和 DDT 的暴露导致 GSI 和血浆 E2 水平下降。停止接触农药后，所有研究组织中暴露鱼类体内的 HCH 均有恢复，而暴露于 DDT 的鱼类仅在肝脏中恢复。γ-HCH 暴露的鱼类也记录到了 E2 产量的恢复，而 DDT 暴露的鱼类则很少记录到。这表明 HCHs 和 DDTs 在组织生物浓度上具有优先顺序（肝>脑>卵巢），并且在研究阶段，HCH/DDT 撤药依赖于恢复。
