Herbal Research Section, Indian Institute of Toxicology Research, 80 M.G. Marg, Lucknow 226001, Uttar Pradesh, India.
Environ Toxicol Pharmacol. 2009 Jan;27(1):62-9. doi: 10.1016/j.etap.2008.08.007. Epub 2008 Sep 2.
Role of oxidative stress has been reported in various diabetic complications including neuropathy, nephropathy and cardiopathy. This study was undertaken to evaluate the protective effect of Bacopa monnieri, a medicinal plant, on tissue antioxidant defense system and lipid peroxidative status in streptozotocin-induced diabetic rats. Extract of B. monnieri was administered orally, once a day for 15 days (at doses 50, 125 and 250mg/(kgbw)) to diabetic rats. Activity of antioxidant enzymes (SOD, Catalase, and GPx), levels of GSH and lipid peroxidation were estimated in kidney, cerebrum, cerebellum and midbrain of diabetic rats and compared to reference drug, Glibenclamide. Administration of plant extract to diabetic rats showed significant reversal of disturbed antioxidant status and peroxidative damage. Significant increase in SOD, CAT, GPx activity and levels of GSH was observed in extract treated diabetic rats. The present study indicates that extract of B. monnieri modulates antioxidant activity, and enhances the defense against ROS generated damage in diabetic rats.
氧化应激在各种糖尿病并发症中都有报道，包括神经病变、肾病和心脏病。本研究旨在评估药用植物假马齿苋对链脲佐菌素诱导的糖尿病大鼠组织抗氧化防御系统和脂质过氧化状态的保护作用。假马齿苋提取物每天口服一次，连续 15 天（剂量为 50、125 和 250mg/（kgbw））给予糖尿病大鼠。在糖尿病大鼠的肾脏、大脑、小脑和中脑中评估抗氧化酶（SOD、Catalase 和 GPx）的活性、GSH 水平和脂质过氧化，并与参考药物格列本脲进行比较。向糖尿病大鼠给予植物提取物显示出对紊乱的抗氧化状态和过氧化损伤的显著逆转。在提取物处理的糖尿病大鼠中观察到 SOD、CAT、GPx 活性和 GSH 水平的显著增加。本研究表明，假马齿苋提取物可调节抗氧化活性，并增强糖尿病大鼠对 ROS 产生的损伤的防御能力。
