Donghu Experimental Station of Lake Ecosystems, State Key Laboratory for Freshwater Ecology and Biotechnology of China, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430072, PR China.
Environ Toxicol Pharmacol. 2009 May;27(3):350-6. doi: 10.1016/j.etap.2008.12.001. Epub 2008 Dec 11.
The planktivorous filter-feeding silver carp (Hypophthalmichthys molitrix) and bighead carp (Aristichthys nobilis) are the attractive candidates for bio-control of plankton communities to eliminate odorous populations of cyanobacteria. However, few studies focused on the health of such fishes in natural water body with vigorous toxic blooms. Blood parameters are useful and sensitive for diagnosis of diseases and monitoring of the physiological status of fish exposed to toxicants. To evaluate the impact of toxic cyanobacterial blooms on the planktivorous fish, 12 serum chemistry variables were investigated in silver carp and bighead carp for 9 months, in a large net cage in Meiliang Bay, a hypereutrophic region of Lake Taihu. The results confirmed adverse effects of cyanobacterial blooms on two phytoplanktivorous fish, which mainly characterized with potential toxicogenomic effects and metabolism disorders in liver, and kidney dysfunction. In addition, cholestasis was intensively implied by distinct elevation of all four related biomarkers (ALP, GGT, DBIL, TBIL) in bighead carp. The combination of LDH, AST activities and DBIL, URIC contents for silver carp, and the combination of ALT, ALP activities and TBIL, DBIL, URIC concentrations for bighead carps were found to most strongly indicate toxic effects from cyanobacterial blooms in such fishes by a multivariate discriminant analysis.
滤食性浮游生物的白鲢（Hypophthalmichthys molitrix）和鳙鱼（Aristichthys nobilis）是控制浮游生物群落以消除有气味的蓝藻种群的有吸引力的候选生物。然而，很少有研究关注在有毒藻类水华活跃的天然水体中这些鱼类的健康状况。血液参数对于诊断疾病和监测暴露于毒物的鱼类的生理状况非常有用和敏感。为了评估有毒蓝藻水华对滤食性鱼类的影响，在太湖富营养化地区的梅梁湾的一个大型网箱中，对鲢鱼和鳙鱼进行了 9 个月的研究，共检测了 12 种血清化学变量。结果证实了蓝藻水华对两种浮游植物食性鱼类的不利影响，这主要表现为肝毒性和代谢紊乱，以及肾功能障碍。此外，在鳙鱼中，所有四个相关生物标志物（ALP、GGT、DBIL 和 TBIL）的明显升高强烈暗示了胆汁淤积。通过多元判别分析发现，鲢鱼中 LDH、AST 活性与 DBIL、URIC 含量的组合，以及鳙鱼中 ALT、ALP 活性与 TBIL、DBIL、URIC 浓度的组合最能强烈表明鱼类受到蓝藻水华的毒性影响。
