印度北部德里人群谷胱甘肽 S-转移酶 M1 和 T1 的遗传多态性。
Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India.
机构信息
Division of Biochemistry & Biotechnology, National Institute of Communicable Diseases, 22, Sham Nath Marg, Delhi 110054, India.
出版信息
Environ Toxicol Pharmacol. 2009 Jul;28(1):25-9. doi: 10.1016/j.etap.2009.01.010. Epub 2009 Feb 11.
Glutathione S-transferases (GSTs), protect cells from reactive chemical intermediates and oxidative stress. Among different classes of GSTs, GSTM1 (Mu) and GSTT1 (theta) are found to be genetically deleted. Present study was intended to genotype homozygous null distribution of GSTM1 and GSTT1 in healthy individuals of Delhi, located in Northern India. Out of 309 healthy individuals included in this study, we have found genetic deletion in 21% and 27.4%, GSTM1 and GSTT1 genes, respectively. A small proportion (0.7%) population showed deletion of both the genes. The prevalence of the GSTM1()0/0 and GSTT1()0/0 genotypes varied within India compared to communities in Chinese, Japanese, Korean and Caucasian.
谷胱甘肽 S-转移酶 (GSTs) 可保护细胞免受活性化学中间体和氧化应激的影响。在不同类别的 GSTs 中，发现 GSTM1 (Mu) 和 GSTT1 (theta) 存在遗传缺失。本研究旨在对位于印度北部的德里的健康个体中 GSTM1 和 GSTT1 的纯合缺失基因型进行基因分型。在纳入本研究的 309 名健康个体中，我们分别发现 GSTM1 和 GSTT1 基因的遗传缺失率为 21%和 27.4%。一小部分（0.7%）人群表现出两个基因的缺失。与中国、日本、韩国和高加索人群相比，印度不同社区的 GSTM1(*0/0) 和 GSTT1(*0/0) 基因型的流行率存在差异。
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